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Found 92 from German Cancer Research Center
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613561(CHEMBL5283285)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-labeled PSMA-10 by gamma counting assayMore data for this Ligand-Target Pair
Ligand Info
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TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613559(CHEMBL5270513)
Affinity DataKi:  0.530nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-labeled PSMA-10 by gamma counting assayMore data for this Ligand-Target Pair
Ligand Info
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TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613566(CHEMBL5275438)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-labeled PSMA-10 by gamma counting assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613557(CHEMBL5279851)
Affinity DataKi:  2nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-labeled PSMA-10 by gamma counting assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50544833(PSMA-617 | Vipivotide tetraxetan)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-labeled PSMA-10 by gamma counting assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613560(CHEMBL5279511)
Affinity DataKi:  6.20nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-labeled PSMA-10 by gamma counting assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613567(CHEMBL5287113)
Affinity DataKi:  6.30nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-labeled PSMA-10 by gamma counting assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613558(CHEMBL5268818)
Affinity DataKi:  7.5nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-labeled PSMA-10 by gamma counting assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613562(CHEMBL5268703)
Affinity DataKi:  8.90nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-labeled PSMA-10 by gamma counting assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613568(CHEMBL5284385)
Affinity DataKi:  9.30nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-labeled PSMA-10 by gamma counting assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50089451(CHEMBL3578202)
Affinity DataKi:  12nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-labeled PSMA-10 by gamma counting assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613563(CHEMBL5282249)
Affinity DataKi:  13nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-labeled PSMA-10 by gamma counting assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613556(CHEMBL5289867)
Affinity DataKi:  15nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-labeled PSMA-10 by gamma counting assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613564(CHEMBL5267599)
Affinity DataKi:  18nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-labeled PSMA-10 by gamma counting assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613570(CHEMBL5281545)
Affinity DataKi:  19nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-labeled PSMA-10 by gamma counting assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613569(CHEMBL5272927)
Affinity DataKi:  21nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-labeled PSMA-10 by gamma counting assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613571(CHEMBL5269260)
Affinity DataKi:  25nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-labeled PSMA-10 by gamma counting assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613565(CHEMBL5274946)
Affinity DataKi:  29nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-labeled PSMA-10 by gamma counting assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSolute carrier organic anion transporter family member 1B3(Homo sapiens (Human))
German Cancer Research Center

Curated by PDSP Ki Database
LigandPNGBDBM86671(CAS_60719 | MK 571 | NSC_60719)
Affinity DataKi:  600nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 1B3(Homo sapiens (Human))
German Cancer Research Center

Curated by PDSP Ki Database
LigandPNGBDBM86672(CAS_2909 | Cyclosporin A | NSC_2909)
Affinity DataKi:  1.20E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
German Cancer Research Center

Curated by PDSP Ki Database
LigandPNGBDBM86671(CAS_60719 | MK 571 | NSC_60719)
Affinity DataKi:  8.50E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1.20nMAssay Description:The kinase activity was determined by incubation of enzyme and its substrate, and test compound, in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
German Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50106517(6-(4-Bromo-thiophen-2-ylmethoxy)-9H-purin-2-ylamin...)
Affinity DataIC50:  9nMAssay Description:In vitro inhibition of MGMT using cell free extracts from HeLa S3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
German Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50106518(2-{10-[2-Amino-6-(4-bromo-thiophen-2-ylmethoxy)-pu...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibition of MGMT using cell free extracts from HeLa S3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
German Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50106510(2-{12-[2-Amino-6-(4-bromo-thiophen-2-ylmethoxy)-pu...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibition of MGMT using cell free extracts from HeLa S3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
German Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50106511(2-{8-[2-Amino-6-(4-bromo-thiophen-2-ylmethoxy)-pur...)
Affinity DataIC50:  32nMAssay Description:In vitro inhibition of MGMT using cell free extracts from HeLa S3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
German Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50106515(7-Benzyloxy-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-y...)
Affinity DataIC50:  38nMAssay Description:In vitro inhibition of MGMT using cell free extracts from HeLa S3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha [V123M](Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50: <45nMpH: 6.8 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50: <45nMpH: 6.8 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [L49I,Q181K,T183A](Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50: <45nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataIC50: <45nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha [L49I,V123M,E127D,Q181K,T183A](Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50: <45nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [V123M,Q181K,T183A](Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50: <45nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [Q181K,T183A](Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50: <45nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [Q181K,T183A](Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM14030(KT5720 | hexyl (15R,16S,18S)-16-hydroxy-15-methyl-...)
Affinity DataIC50: <45nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha [E127D](Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50: <45nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [T183A](Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50: <45nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [T183A](Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM14030(KT5720 | hexyl (15R,16S,18S)-16-hydroxy-15-methyl-...)
Affinity DataIC50: <45nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha [L49I](Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  47nMpH: 6.8 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [L49I,V123M,Q181K,T183A](Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  51nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM14030(KT5720 | hexyl (15R,16S,18S)-16-hydroxy-15-methyl-...)
Affinity DataIC50:  56nMpH: 6.8 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha [L49I,Q181K,T183A](Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataIC50:  58nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [V123M,Q181K,T183A](Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM14030(KT5720 | hexyl (15R,16S,18S)-16-hydroxy-15-methyl-...)
Affinity DataIC50:  68nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha [L49I,V123M,Q181K,T183A](Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataIC50:  89nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [Q181K,T183A](Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataIC50:  109nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [T183A](Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataIC50:  109nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [L49I,V123M,E127D,Q181K,T183A](Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataIC50:  149nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha [V123M](Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM14030(KT5720 | hexyl (15R,16S,18S)-16-hydroxy-15-methyl-...)
Affinity DataIC50:  222nMpH: 6.8 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha [V123M,Q181K,T183A](Bos taurus (bovine))
German Cancer Research Center

LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataIC50:  223nMAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetMethylated-DNA--protein-cysteine methyltransferase(Homo sapiens (Human))
German Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50106514(2-{4-[2-Amino-6-(4-bromo-thiophen-2-ylmethoxy)-pur...)
Affinity DataIC50:  250nMAssay Description:In vitro inhibition of MGMT using cell free extracts from HeLa S3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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